The Boerckel lab’s philosophy is that, if one wants to build a tissue, they should look to how the embryo builds that tissue. To this end, we aim to reciprocally map the mechanisms of development and regeneration, using mechanobiology as a lens. Our team seeks to understand how mechanical cues influence embryonic development and tissue regeneration to enable new therapies for congenital diseases and regenerative medicine. Current work in the lab focuses on feedback dynamics of cytoskeletal regulation and RhoA signaling, mechanisms of mechanotransduction through YAP/TAZ, regulation of skeletal and vascular morphogenesis by embryonic mechanical cues, and mechanoregulation of tissue regeneration in fracture healing and tendinopathy. Motivated by these fundamental questions, we use a variety of tools from optogenetic protein engineering to exercise physiology in mice. We value diverse, open, collaborative, and collegial science.